Description
IGF-1 LR3 0.1mg & 1mg — Long R3 IGF-1 Research Material
Overview
IGF-1 LR3, commonly called Long R3 IGF-1, is an engineered analog of human insulin-like growth factor-1.
The molecule contains a substitution at position 3 and an N-terminal extension. These modifications reduce its affinity for IGF-binding proteins compared with native IGF-1 and can increase its availability in experimental systems.
NovasynLabs IGF-1 LR3 is available in 0.1mg and 1mg research presentations.
IGF-1 Biology
Insulin-like growth factor-1 is an important growth factor involved in cellular proliferation, differentiation, metabolism, and tissue biology.
IGF-1 exerts much of its biological activity through the type 1 IGF receptor, a receptor tyrosine kinase.
Activation of IGF-1 receptor signaling can influence intracellular pathways including PI3K-Akt and MAPK-related signaling.
Why Long R3 IGF-1 Is Studied
Native IGF-1 interacts extensively with IGF-binding proteins.
The engineered Long R3 form was designed to reduce this interaction. Research suppliers and cell-culture manufacturers describe Long R3 IGF-1 as having substantially reduced affinity for IGF-binding proteins compared with native IGF-1.
This characteristic makes it useful in experimental cell-culture systems where researchers require a growth-factor analog with altered binding characteristics.
Cell-Culture Research
Long R3 IGF-1 is used in research and biotechnology applications involving mammalian cell culture.
Commercial cell-culture products have used Long R3 IGF-1 as a growth-factor supplement for systems including CHO and HEK-derived cells.
Research applications can include studies of:
– IGF-1 receptor signaling
– Cell proliferation
– Cell survival
– Protein synthesis
– Growth-factor signaling
– Mammalian cell culture
– Cellular metabolism
– PI3K-Akt signaling
– MAPK signaling
0.1mg and 1mg Presentations
IGF-1 LR3 0.1mg provides a smaller quantity for research workflows where limited material is required.
IGF-1 LR3 1mg provides a larger research presentation for laboratories requiring additional material.
The principal difference is the amount supplied.
Analytical Quality
Growth-factor proteins require appropriate characterization.
Depending on the research application, analytical approaches may include HPLC, SDS-PAGE, mass spectrometry, immunoassays, and functional cell-based assays.
Researchers should evaluate batch documentation and analytical specifications before experimental use.
Research-Use Statement
IGF-1 LR3 is supplied for laboratory research and analytical applications only.
The product should not be represented as a human performance-enhancing treatment or as a medication.
Summary
IGF-1 LR3 is an engineered IGF-1 analog developed to modify interaction with IGF-binding proteins. Its altered structure makes it useful for research involving IGF receptor signaling and mammalian cell culture.
NovasynLabs provides IGF-1 LR3 in 0.1mg and 1mg research presentations.
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